Free CME

Sickle cell disease (SCD) is the most common monogenic blood disorder, affecting millions of people worldwide and approximately 100,000 Americans. Although it may be found in various areas of the world, SCD predominantly affects individuals of African or Hispanic heritage. It is caused by the inheritance of b-globin alleles that code for hemoglobin S, resulting in an amino acid substitution in hemoglobin’s b chain and clinical disease. Patients with SCD have impaired circulation, and lysis of the erythrocytes contributes to a chronic inflammatory response, causing severe pain and less efficient oxygen delivery. The hallmark clinical features of SCD are hemolytic anemia and painful vaso-occlusive crises (VOCs), which may lead to emergency department visits, hospitalization, and potentially fatal complications such as acute chest syndrome, stroke, or pneumonia. In one US study, 45% of deaths among people with SCD were related to cardiopulmonary causes, and VOCs alone have been shown to increase the risk of death by 50%. SCD may disrupt employment or school and is associated with a significant reduction in quality of life. This learning activity has been designed to bring HCPs’ knowledge of rationale behind treatment of SCD up to date and to enhance their competence and performance in the condition’s management.

CME is available in many groups including:
• Disclosure and Apology Series
• Patient Safety Series
• Improving Communications in Health Care
• Key Risk Areas
• Managing a Medical Malpractice Case

Target Audience: Physicians specializing in Risk Management

All courses are about new and current imaging modalities, with a primary focus on breast imaging.

Courses fall into these groups:
• Advanced MRI Tutorials
• Automated Breast Ultrasound
• Breast MRI
• Breast Stereotactic Biopsy
• Breast Tomosynthesis (DBT)
• Breast Ultrasound
• DXA
• Liver LI-RADS
• Prostate MRI

Target Audience: Radiologists

Activity Description / Statement of Need:

In this online, self-learning activity:

Thymidine kinase 2 deficiency (TK2D) is an ultrarare mitochondrial disease caused by recessive mutations in the TK2 gene and manifesting as a form of mitochondrial DNA depletion/deletion syndrome (MDDS) and mitochondrial myopathy. Under normal conditions, the TK2 gene encodes for the thymidine kinase enzyme present in the mitochondria, which is responsible for the phosphorylating of pyrimidine nucleosides, deoxythymidine, and deoxycytidine. These are the first steps in mitochondrial DNA synthesis, and researchers speculate that TK2 mutations affect muscle tissue because its higher energy demands make it most susceptible to mitochondrial impairment. Mutational analyses of patients with MDDS have found that approximately 15% have TK2 mutations, which may be extrapolated to about 600 to 2,700 individuals in the US.

Target Audience:

HCPs including but not limited to: neurologists, pediatric neurologists, pediatricians, primary care providers, pulmonologists, gastroenterologists, and medical geneticists; physician assistants, nurse practitioners, pharmacists, and nurses who practice in the aforementioned areas of specialty; and any other HCPs with an interest in or who may clinically encounter patients with TK2D.

Pri-Med’s P.A.C.T. Update: Practical Approaches to Comprehensive Treatment of Pain 2024-25 curriculum focuses on improving practitioners’ ability to recognize, diagnose, and classify pain; educating clinicians on the full spectrum of pain management options, including non-opioid pharmacologic interventions; and providing risk reduction strategies through integration of opioids into individualized pain management plans. Clinicians will learn to recognize signs and symptoms of opioid dependence and abuse in order to optimally manage patients’ pain and medication use.

Learning Objectives

• Discuss the definitions and mechanisms of pain
• Identify risk factors and stratification for opioid-related aberrant behavior and opioid use disorder as part of the initial assessment
• Apply individualized recommendations for nonpharmacologic and non-opioid treatment options for patients in pain
• Review general characteristics of opioid analgesics including their intended use and risks
• Differentiate among tolerance, physical dependence, and manifestations of opioid use disorder
• Recognize best practices to reduce the risks associated with prescription of opioid analgesics, including safe storage and disposal
• Anticipate and manage adverse effects of opioid use including signs of opioid overdose and the use of naloxone
• Select approaches to safely initiate opioids for the treatment of acute pain and chronic pain
• Identify strategies for ongoing safe and effective use of opioids in patients with chronic pain, including titration, referral, and discontinuation, when appropriate
• Summarize counseling strategies for caregivers and patients on opioid therapy
• Act appropriately to evaluate, treat, or refer patients with opioid use disorder

Target Audience: Cardiologists and PCPs; physician assistants, nurse practitioners, and pharmacists who practice in Cardiology and Internal Medicine, with overlaps in Endocrinology and Hematology depending on the course topic.

Target Audience: Physicians focusing on Allergy, Rheumatology.

Physicians specializing in Allergy or Dermatology.

Target Audience: Physicians focusing on Pain Management

Target Audience:
Physicians specializing in Immunology, Nephrology, Urology

Activity Description / Statement of Need:
In this online, self-learning activity:

Hospital-acquired pneumonia (HAP) occurs at an estimated rate of five to ten per 1,000 hospital admissions and is the most common cause of hospital-acquired infection in the United States. It is defined as pneumonia that develops at least 48 hours after hospital admission and did not appear to be incubating at the time of admission. A significant subset of HAP that occurs most frequently in intensive care units (ICUs) is ventilator-associated pneumonia (VAP), which is defined as pneumonia that occurs more than 48 to 72 hours after tracheal intubation and is thought to affect approximately 10 to 20% of patients who receive mechanical ventilation for more than 48 hours. Altered mechanical defenses, such as impaired ciliary motion and mucus secretion, increase the susceptibility for acquiring pneumonia in intubated patients, with over 90% of pneumonia episodes that develop in ICUs occurring in patients who are intubated or mechanically ventilated.

Target Audience:
HCPs including: pulmonologists, infectious disease specialists, and intensivists; physician assistants, nurse practitioners, and pharmacists specializing in infectious disease or critical care; and any other healthcare professionals with an interest in or clinically encounter patients with HAP or VAP.

Activity Description / Statement of Need:

In this online, self-learning activity:

Cervical dystonia is the most common focal dystonia, characterized by involuntary muscular contractions resulting in abnormal head, neck, and shoulder movements in addition to posture that can cause tremor and pain. Early-onset dystonia can begin in infancy, childhood, or adolescence, and it generally progresses from focal to generalized. Adult-onset dystonia usually affects the upper part of the body; the origin of the dystonia determines the risk of spread. Cervical dystonia may appear as torticollis, laterocollis, anterocollis, or retrocollis. It may be distinguished from nondystonic hand tremor and essential tremor by the absence of limb tremor and the manner of neck movement. However, it is more difficult to distinguish from pseudodystonias, resulting in misdiagnosis and inappropriate treatment.

Target Audience:

The following HCPs: medical neurologists; physician assistants, nurse practitioners, and pharmacists who practice in neurology; and other clinicians who commonly encounter patients with cervical dystonia.