Hematology and Oncology Board Review Sample Question 1
A 32-year-old female is being evaluated in a New Jersey fertility clinic. She has a history of sensorineural hearing loss and was found to have marked thrombocytopenia (platelet count 17 x 10^9/L). The other cell counts were normal and she reports no significant bleeding history despite multiple surgeries. Her peripheral smears are depicted below. What do the inclusions (arrows) in the neutrophils consist of?
- AMYH9 protein aggregates
- BLysosomal aggregates
- ENuclear material
Hematology and Oncology Board Review Sample Question 2
The blood bank receives a type and screen sample on a 3-year-old Caucasian boy with chronic granulomatous disease (CGD).He types as O, Rh-positive, and his screen is positive on both cells. He has been transfused in the past. A panel work-up reveals the following. You are concerned that this patient may be negative for a high-incidence antigen. This patient is most likely to be phenotypically negative (or very weakly expressing) for which high-incidence antigen?
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“We’ve needed a HemOnc question bank for a while... glad it’s finally here. The topics in your question bank are similar to the HemOnc board exam and I’m grateful for the resource.
Ben Steube, MD, Pathology, Hematology, MD Anderson Cancer Center