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Neurology Board Review Sample Question 1

A 30-year-old man with a history of frequent migraines with aura has had several TIAs. Family history reveals that his father also had migraines with aura and later developed an unknown neurologic disease. When questioned further, the patient says his father developed dementia in his fifties, had multiple strokes and TIAs, and lost the ability to walk, requiring a wheelchair shortly before his death at age 61. What gene is affected in this disorder? 

  • ANOTCH1 gene
  • BTransfer RNA gene at mt3243
  • CP/Q-type calcium channel receptor gene
  • DNOTCH3 gene
  • ECACNA1A gene

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