Atypical hemolytic uremic syndrome (aHUS): therapeutic updates and optimizing treatment

Details

Atypical hemolytic uremic syndrome (aHUS) is a disease in which the complement system is activated in an uncontrolled manner outside the presence of coexisting disease, resulting in platelet activation, damage to endothelial cells, and a range of clinical sequelae including: which may ultimately lead to kidney failure; systemic thrombotic microangiopathy;anemia; and thrombocytopenia.

After completing this course, you will better be able to:

• Describe the pathophysiology of aHUS such that it might informs pairing with present treatment mechanisms
• Describe aHUS diagnostic methods, differential diagnosis, and the benefits of earlier diagnosis
• Describe available therapies used for treatment of aHUS and summarize the literature supporting use of those therapies
• Design an evidence-based treatment plan for a patient with aHUS

Target Audience: hematologists, nephrologists, and primary care physicians; physician assistants, nurse practitioners, nurses, and pharmacists specializing in hematology and transplant medicine; and any other healthcare professionals with an interest in or who may clinically encounter patients with aHUS.