Atypical hemolytic uremic syndrome (aHUS): best practices and effective management
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Activity Description / Statement of Need:
Atypical hemolytic uremic syndrome (aHUS) is a disease in which the complement system is activated in an uncontrolled manner outside the presence of coexisting disease, resulting in platelet activation, damage to endothelial cells, and a range of clinical sequelae, including kidney failure, systemic thrombotic microangiopathy, anemia, and thrombocytopenia. The disease may arise from any of a number of genetic mutations of the complement system or the presence of anti-complement factor H. While it is estimated to occur at an equally commonly between males and females, the disease is rare, with an incidence of about 2 to 9 people per million and a prevalence of about 5 per million.
This educational activity identifies the critical components of the management process and offer solutions to close gaps in diagnosis and care, with the ultimate goals being the improvement of aHUS management, treatment adherence, and health and cost outcomes.
Hematologists and primary care physicians; physician assistants, nurse practitioners, nurses, and pharmacists specializing in hematology and transplant medicine; and any other HCPs with an interest in or who may clinically encounter patients with aHUS.