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Question 1: A 50-year-old patient presents with a history of intermittent burning sensations in the lower extremities. The patient is a strict vegan and exercises regularly. Past medical history is unremarkable, and physical examination is normal. Pertinent laboratory results are shown below. Which of the following is the next step in the evaluation?


  1. Electromyelography and nerve conduction studies

  2. Computed tomography of lumbosacral spine

  3. Therapeutic trial of vitamin B12

  4. Bone marrow examination

  5. Serum methylmalonic acid and homocysteine levels


References: 1. Schrier S. Diagnosis and treatment of vitamin B12 and folate deficiency. UpToDate. 2015. Available from: 2. Schrier S. Etiology and clinical manifestations of vitamin B12 and folate deficiency. UpToDate. 2016. Available from:


Question 2: A 22 year-old African American male with sickle cell disease presents to the emergency department complaining of profound fatigue for approximately 1 week. Two weeks prior to presentation his hemoglobin was 10.2 g/dL but is now 6.5 g/dL. He is given 2 units of packed red cells. The clinician suspects an acute parvovirus B19 infection. Which blood group antigen is the receptor for parvovirus?


  1. Duffy antigen

  2. Kell antigen

  3. P antigen

  4. Kidd antigen

  5. Pk antigen


Hematology & Oncology ABIM Recertification (MOC) Exam Practice Questions

Prepare to pass the Hematology & Oncology ABIM Recertification exams with more than 700 board-style questions including detailed explanations and evidence-based rationales. Content is targeted to both the American Board of Internal Medicine (ABIM) Hematology MOC Exam and the Oncology MOC exam.



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We’ve needed a HemOnc question bank for a while... glad it’s finally here. The topics in your question bank are similar to the HemOnc board exam and I’m grateful for the resource.” - Ben Steuben, MD, Pathology, Hematology, MD Anderson Cancer Center