She has a history of sensorineural hearing loss and was found to have marked thrombocytopenia (platelet count 17 x 10^9/L). The other cell counts were normal and she reports no significant bleeding history despite multiple surgeries. Her peripheral smears are depicted below. What do the inclusions (arrows) in the neutrophils consist of?
MYH9 protein aggregates
Reference: Savoia A, Balduini C. MYH9-Related Disorders. In Pagon RA, Bird TD, Dolan CR, Stephens K, Adam MP, editors. Gene Reviews. Seattle, WA: University of Washington, Seattle. 1993-2008, Nov 20 [Updated 2011 April 05].
Reference: AABB Technical Manual, 18th Edition
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