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Question 1: A 32-year-old female is being evaluated in a New Jersey fertility clinic.

She has a history of sensorineural hearing loss and was found to have marked thrombocytopenia (platelet count 17 x 10^9/L). The other cell counts were normal and she reports no significant bleeding history despite multiple surgeries. Her peripheral smears are depicted below. What do the inclusions (arrows) in the neutrophils consist of?

  1. MYH9 protein aggregates

  2. Lysosomal aggregates

  3. Ehrlichia

  4. Mucopolysaccharides

  5. Nuclear material


Reference: Savoia A, Balduini C. MYH9-Related Disorders. In Pagon RA, Bird TD, Dolan CR, Stephens K, Adam MP, editors. Gene Reviews. Seattle, WA: University of Washington, Seattle. 1993-2008, Nov 20 [Updated 2011 April 05].

Question 2: The blood bank receives a type and screen sample on a 3-year-old Caucasian boy with chronic granulomatous disease (CGD).He types as O, Rh-positive, and his screen is positive on both cells. He has been transfused in the past. A panel work-up reveals the following. You are concerned that this patient may be negative for a high-incidence antigen. This patient is most likely to be phenotypically negative (or very weakly expressing) for which high-incidence antigen?

  1. k

  2. H

  3. Fy3

  4. Jk3

  5. U


Reference: AABB Technical Manual, 18th Edition

Hematology & Oncology Question Bank

This Hematology and Oncology question bank is targeted to the ABIM initial certification exam for Medical Oncology. The question bank also covers material likely to appear on the Hematology Board Exam. Each question is categorized so that students can study a category at a time, or take questions from multiple sections. Board review questions are prepared and reviewed by top physicians certified in Medical Oncology and Hemepath.



Developed by top faculty and practicing physicians, BoardVitals helps thousands of doctors prepare for board certification exams and complete their CME requirements. BoardVitals is trusted by leading medical institutions including Harvard, Yale, Mt. Sinai, and Duke.


We’ve needed a HemOnc question bank for a while... glad it’s finally here. The topics in your question bank are similar to the HemOnc board exam and I’m grateful for the resource.” - Ben Steuben, MD, Pathology, Hematology, MD Anderson Cancer Center